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Flow tolerant adhesion of a bacterial pathogen to human endothelial cells through interaction with biglycan

Overview of attention for article published in Journal of Infectious Diseases, January 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (73rd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (60th percentile)

Mentioned by

twitter
6 tweeters
facebook
1 Facebook page

Readers on

mendeley
6 Mendeley
citeulike
1 CiteULike
Title
Flow tolerant adhesion of a bacterial pathogen to human endothelial cells through interaction with biglycan
Published in
Journal of Infectious Diseases, January 2016
DOI 10.1093/infdis/jiw003
Pubmed ID
Authors

Salo, Jemiina, Pietikäinen, Annukka, Söderström, Mirva, Auvinen, Kaisa, Salmi, Marko, Ebady, Rhodaba, Moriarty, Tara J, Viljanen, Matti K, Hytönen, Jukka, Jemiina Salo, Annukka Pietikäinen, Mirva Söderström, Kaisa Auvinen, Marko Salmi, Rhodaba Ebady, Tara J. Moriarty, Matti K. Viljanen, Jukka Hytönen, Moriarty, Tara J., Viljanen, Matti K.

Abstract

 Bacterial pathogens causing systemic infections disseminate from the initial infection focus to the target organs usually through the blood vasculature. To be able to colonize various organs, bacteria need to adhere to the endothelial cells of the vascular wall, and the adhesion must be strong enough to resist the shear force of the blood flow. Borrelia burgdorferi sensu lato (s.l.) spirochetes, the causative agents of the tick-borne Lyme borreliosis, disseminate hematogenously from the tick bite site to the joints, the heart and the central nervous system of the patient.  We used both wild type and genetically modified B. burgdorferi s.l. bacteria, recombinant borrelia adhesins, and an array of adhesion assays carried out both under stationary and flow conditions to investigate the molecular mechanisms of borrelial adhesion to human endothelial cells.  Borrelia garinii, a member of the B. burgdorferi s.l. complex, adhered to biglycan expressed by human endothelial cells in a flow tolerant manner. The adhesion was mediated by the DbpA and B surface molecules of B. garinii.  The proteoglycan biglycan is a receptor molecule for flow resistant adhesion of the bacterial pathogen B. garinii on human endothelial cells.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 17%
Unknown 5 83%

Demographic breakdown

Readers by professional status Count As %
Researcher 2 33%
Librarian 2 33%
Professor 1 17%
Student > Ph. D. Student 1 17%
Readers by discipline Count As %
Immunology and Microbiology 2 33%
Social Sciences 2 33%
Philosophy 1 17%
Biochemistry, Genetics and Molecular Biology 1 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 April 2017.
All research outputs
#1,854,195
of 8,058,252 outputs
Outputs from Journal of Infectious Diseases
#1,774
of 6,239 outputs
Outputs of similar age
#84,608
of 317,242 outputs
Outputs of similar age from Journal of Infectious Diseases
#56
of 141 outputs
Altmetric has tracked 8,058,252 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,239 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 317,242 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 141 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.