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Flow-Tolerant Adhesion of a Bacterial Pathogen to Human Endothelial Cells Through Interaction With Biglycan

Overview of attention for article published in Journal of Infectious Diseases, January 2016
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (73rd percentile)
  • Good Attention Score compared to outputs of the same age and source (71st percentile)

Mentioned by

twitter
7 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
3 Dimensions

Readers on

mendeley
9 Mendeley
citeulike
1 CiteULike
Title
Flow-Tolerant Adhesion of a Bacterial Pathogen to Human Endothelial Cells Through Interaction With Biglycan
Published in
Journal of Infectious Diseases, January 2016
DOI 10.1093/infdis/jiw003
Pubmed ID
Authors

Jemiina Salo, Annukka Pietikäinen, Mirva Söderström, Kaisa Auvinen, Marko Salmi, Rhodaba Ebady, Tara J. Moriarty, Matti K. Viljanen, Jukka Hytönen

Abstract

 Bacterial pathogens causing systemic infections disseminate from the initial infection focus to the target organs usually through the blood vasculature. To be able to colonize various organs, bacteria need to adhere to the endothelial cells of the vascular wall, and the adhesion must be strong enough to resist the shear force of the blood flow. Borrelia burgdorferi sensu lato (s.l.) spirochetes, the causative agents of the tick-borne Lyme borreliosis, disseminate hematogenously from the tick bite site to the joints, the heart and the central nervous system of the patient.  We used both wild type and genetically modified B. burgdorferi s.l. bacteria, recombinant borrelia adhesins, and an array of adhesion assays carried out both under stationary and flow conditions to investigate the molecular mechanisms of borrelial adhesion to human endothelial cells.  Borrelia garinii, a member of the B. burgdorferi s.l. complex, adhered to biglycan expressed by human endothelial cells in a flow tolerant manner. The adhesion was mediated by the DbpA and B surface molecules of B. garinii.  The proteoglycan biglycan is a receptor molecule for flow resistant adhesion of the bacterial pathogen B. garinii on human endothelial cells.

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 11%
Unknown 8 89%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 33%
Student > Bachelor 2 22%
Librarian 2 22%
Student > Ph. D. Student 1 11%
Professor 1 11%
Other 0 0%
Readers by discipline Count As %
Medicine and Dentistry 2 22%
Biochemistry, Genetics and Molecular Biology 2 22%
Social Sciences 2 22%
Immunology and Microbiology 2 22%
Philosophy 1 11%
Other 0 0%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 October 2018.
All research outputs
#3,161,253
of 12,196,947 outputs
Outputs from Journal of Infectious Diseases
#3,511
of 10,355 outputs
Outputs of similar age
#88,652
of 333,544 outputs
Outputs of similar age from Journal of Infectious Diseases
#34
of 123 outputs
Altmetric has tracked 12,196,947 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 10,355 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.4. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 333,544 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 123 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.