↓ Skip to main content

Oxford University Press

Article Metrics

Positive selection on a regulatory insertion-deletion polymorphism in FADS2 influences apparent endogenous synthesis of arachidonic acid

Overview of attention for article published in Molecular Biology and Evolution, March 2016
Altmetric Badge

About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#1 of 2,643)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Mentioned by

news
67 news outlets
blogs
9 blogs
twitter
195 tweeters
facebook
18 Facebook pages
googleplus
12 Google+ users

Readers on

mendeley
54 Mendeley
citeulike
3 CiteULike
Title
Positive selection on a regulatory insertion-deletion polymorphism in FADS2 influences apparent endogenous synthesis of arachidonic acid
Published in
Molecular Biology and Evolution, March 2016
DOI 10.1093/molbev/msw049
Pubmed ID
Authors

Kumar S.D. Kothapalli, Kaixiong Ye, Maithili S. Gadgil, Susan E. Carlson, Kimberly O. O’Brien, Ji Yao Zhang, Hui Gyu Park, Kinsley Ojukwu, James Zou, Stephanie S. Hyon, Kalpana S. Joshi, Zhenglong Gu, Alon Keinan, J. Thomas Brenna, Kumar S. D. Kothapalli, , Kaixiong Ye, J.Thomas Brenna, Kothapalli, Kumar S. D., Ye, , Kaixiong, Gadgil, Maithili S., Carlson, Susan E., O’Brien, Kimberly O., Zhang, Ji Yao, Park, Hui Gyu, Ojukwu, Kinsley, Zou, James, Hyon, Stephanie S., Joshi, Kalpana S., Gu, Zhenglong, Keinan, Alon, Brenna, J.Thomas

Abstract

Long chain polyunsaturated fatty acids (LCPUFA) are bioactive components of membrane phospholipids and serve as substrates for signaling molecules. LCPUFA can be obtained directly from animal foods or synthesized endogenously from 18 carbon precursors via the FADS2 coded enzyme. Vegans rely almost exclusively on endogenous synthesis to generate LCPUFA and we hypothesized that an adaptive genetic polymorphism would confer advantage. The rs66698963 polymorphism, a 22-bp insertion-deletion within FADS2, is associated with basal FADS1 expression, and coordinated induction of FADS1 and FADS2 in vitro. Here, we determined rs66698963 genotype frequencies from 234 individuals of a primarily vegetarian Indian population and 311 individuals from the US. A much higher I/I genotype frequency was found in Indians (68%) than in the US (18%). Analysis using 1000 Genomes Project data confirmed our observation, revealing a global I/I genotype of 70% in South Asians, 53% in Africans, 29% in East Asians, and 17% in Europeans. Tests based on population divergence, site frequency spectrum, and long-range haplotype consistently point to positive selection encompassing rs66698963 in South Asian, African, and some East Asian populations. Basal plasma phospholipid arachidonic acid (ARA) status was 8% greater in I/I compared with D/D individuals. The biochemical pathway product-precursor difference, ARA minus linoleic acid, was 31% and 13% greater for I/I and I/D compared with D/D, respectively. This study is consistent with previous in vitro data suggesting that the insertion allele enhances n-6 LCPUFA synthesis and may confer an adaptive advantage in South Asians because of the traditional plant-based diet practice.

Twitter Demographics

The data shown below were collected from the profiles of 195 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 7%
Switzerland 1 2%
Kenya 1 2%
Poland 1 2%
Finland 1 2%
Netherlands 1 2%
Canada 1 2%
New Zealand 1 2%
Unknown 43 80%

Demographic breakdown

Readers by professional status Count As %
Researcher 15 28%
Student > Ph. D. Student 10 19%
Professor > Associate Professor 7 13%
Student > Postgraduate 6 11%
Student > Bachelor 4 7%
Other 12 22%
Readers by discipline Count As %
Agricultural and Biological Sciences 27 50%
Medicine and Dentistry 12 22%
Biochemistry, Genetics and Molecular Biology 9 17%
Unspecified 2 4%
Environmental Science 1 2%
Other 3 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 733. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 June 2017.
All research outputs
#3,221
of 7,939,687 outputs
Outputs from Molecular Biology and Evolution
#1
of 2,643 outputs
Outputs of similar age
#325
of 278,778 outputs
Outputs of similar age from Molecular Biology and Evolution
#1
of 75 outputs
Altmetric has tracked 7,939,687 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,643 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.6. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 278,778 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 75 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.