Title |
Diet-related DNA adduct formation in relation to carcinogenesis
|
---|---|
Published in |
Nutrition Reviews, June 2016
|
DOI | 10.1093/nutrit/nuw017 |
Pubmed ID | |
Authors |
Lieselot Y Hemeryck, Lynn Vanhaecke |
Abstract |
The human diet contributes significantly to the initiation and promotion of carcinogenesis. It has become clear that the human diet contains several groups of natural foodborne chemicals that are at least in part responsible for the genotoxic, mutagenic, and carcinogenic potential of certain foodstuffs. Electrophilic chemicals are prone to attack nucleophilic sites in DNA, resulting in the formation of altered nucleobases, also known as DNA adducts. Since DNA adduct formation is believed to signal the onset of chemically induced carcinogenesis, the DNA adduct-inducing potential of certain foodstuffs has been investigated to gain more insight into diet-related pathways of carcinogenesis. Many studies have investigated diet-related DNA adduct formation. This review summarizes work on known or suspected dietary carcinogens and the role of DNA adduct formation in hypothesized carcinogenesis pathways. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 1 | 25% |
United Kingdom | 1 | 25% |
Malaysia | 1 | 25% |
United States | 1 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 75% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 46 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 5 | 11% |
Student > Bachelor | 5 | 11% |
Student > Doctoral Student | 4 | 9% |
Student > Ph. D. Student | 4 | 9% |
Student > Master | 4 | 9% |
Other | 6 | 13% |
Unknown | 18 | 39% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 10 | 22% |
Agricultural and Biological Sciences | 6 | 13% |
Medicine and Dentistry | 4 | 9% |
Immunology and Microbiology | 2 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Other | 5 | 11% |
Unknown | 18 | 39% |