| Title |
Archaic Hominin Introgression in Africa Contributes to Functional Salivary MUC7 Genetic Variation
|
|---|---|
| Published in |
Molecular Biology and Evolution, July 2017
|
| DOI | 10.1093/molbev/msx206 |
| Pubmed ID | |
| Authors |
Duo Xu, Pavlos Pavlidis, Recep Ozgur Taskent, Nikolaos Alachiotis, Colin Flanagan, Michael DeGiorgio, Ran Blekhman, Stefan Ruhl, Omer Gokcumen |
| Abstract |
One of the most abundant proteins in human saliva, mucin-7, is encoded by the MUC7 gene, which harbors copy number variable subexonic repeats (PTS-repeats) that affect the size and glycosylation potential of this protein. We recently documented the adaptive evolution of MUC7 subexonic copy number variation among primates. Yet, the evolution of MUC7 genetic variation in humans remained unexplored. Here, we found that PTS-repeat copy number variation has evolved recurrently in the human lineage, thereby generating multiple haplotypic backgrounds carrying five or six PTS-repeat copy number alleles. Contrary to previous studies, we found no associations between the copy number of PTS-repeats and protection against asthma. Instead, we revealed a significant association of MUC7 haplotypic variation with the composition of the oral microbiome. Furthermore, based on in-depth simulations, we conclude that a divergent MUC7 haplotype likely originated in an unknown African hominin population and introgressed into ancestors of modern Africans. |
X Demographics
The data shown below were collected from the profiles of 93 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 24 | 26% |
| United Kingdom | 7 | 8% |
| Mexico | 4 | 4% |
| Spain | 4 | 4% |
| Japan | 2 | 2% |
| Sweden | 2 | 2% |
| France | 2 | 2% |
| Chile | 1 | 1% |
| Turkey | 1 | 1% |
| Other | 6 | 6% |
| Unknown | 40 | 43% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 64 | 69% |
| Scientists | 29 | 31% |
Mendeley readers
The data shown below were compiled from readership statistics for 110 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 110 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 16 | 15% |
| Student > Ph. D. Student | 14 | 13% |
| Student > Master | 14 | 13% |
| Student > Bachelor | 13 | 12% |
| Professor | 8 | 7% |
| Other | 21 | 19% |
| Unknown | 24 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 33 | 30% |
| Biochemistry, Genetics and Molecular Biology | 18 | 16% |
| Social Sciences | 7 | 6% |
| Arts and Humanities | 7 | 6% |
| Medicine and Dentistry | 4 | 4% |
| Other | 13 | 12% |
| Unknown | 28 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 540. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 May 2023.
All research outputs
#43,776
of 24,896,578 outputs
Outputs from Molecular Biology and Evolution
#11
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Outputs of similar age
#917
of 319,611 outputs
Outputs of similar age from Molecular Biology and Evolution
#1
of 58 outputs
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