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Archaic Hominin Introgression in Africa Contributes to Functional Salivary MUC7 Genetic Variation

Overview of attention for article published in Molecular Biology and Evolution, July 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#2 of 3,384)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Citations

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18 Dimensions

Readers on

mendeley
49 Mendeley
citeulike
1 CiteULike
Title
Archaic Hominin Introgression in Africa Contributes to Functional Salivary MUC7 Genetic Variation
Published in
Molecular Biology and Evolution, July 2017
DOI 10.1093/molbev/msx206
Pubmed ID
Authors

Duo Xu, Pavlos Pavlidis, Recep Ozgur Taskent, Nikolaos Alachiotis, Colin Flanagan, Michael DeGiorgio, Ran Blekhman, Stefan Ruhl, Omer Gokcumen

Abstract

One of the most abundant proteins in human saliva, mucin-7, is encoded by the MUC7 gene, which harbors copy number variable subexonic repeats (PTS-repeats) that affect the size and glycosylation potential of this protein. We recently documented the adaptive evolution of MUC7 subexonic copy number variation among primates. Yet, the evolution of MUC7 genetic variation in humans remained unexplored. Here, we found that PTS-repeat copy number variation has evolved recurrently in the human lineage, thereby generating multiple haplotypic backgrounds carrying five or six PTS-repeat copy number alleles. Contrary to previous studies, we found no associations between the copy number of PTS-repeats and protection against asthma. Instead, we revealed a significant association of MUC7 haplotypic variation with the composition of the oral microbiome. Furthermore, based on in-depth simulations, we conclude that a divergent MUC7 haplotype likely originated in an unknown African hominin population and introgressed into ancestors of modern Africans.

Twitter Demographics

The data shown below were collected from the profiles of 104 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 49 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 18%
Researcher 8 16%
Student > Master 8 16%
Student > Bachelor 7 14%
Professor 5 10%
Other 12 24%
Readers by discipline Count As %
Agricultural and Biological Sciences 22 45%
Biochemistry, Genetics and Molecular Biology 9 18%
Arts and Humanities 4 8%
Social Sciences 4 8%
Unspecified 3 6%
Other 7 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 498. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 November 2018.
All research outputs
#14,032
of 12,380,563 outputs
Outputs from Molecular Biology and Evolution
#2
of 3,384 outputs
Outputs of similar age
#824
of 267,028 outputs
Outputs of similar age from Molecular Biology and Evolution
#1
of 78 outputs
Altmetric has tracked 12,380,563 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,384 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.8. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,028 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 78 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.