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Oxford University Press

CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality

Overview of attention for article published in Nucleic Acids Research, August 2017
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Title
CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality
Published in
Nucleic Acids Research, August 2017
DOI 10.1093/nar/gkx711
Pubmed ID
Authors

Helen Hoffmeister, Andreas Fuchs, Fabian Erdel, Sophia Pinz, Regina Gröbner-Ferreira, Astrid Bruckmann, Rainer Deutzmann, Uwe Schwartz, Rodrigo Maldonado, Claudia Huber, Anne-Sarah Dendorfer, Karsten Rippe, Gernot Längst

Abstract

CHD3 and CHD4 (Chromodomain Helicase DNA binding protein), two highly similar representatives of the Mi-2 subfamily of SF2 helicases, are coexpressed in many cell lines and tissues and have been reported to act as the motor subunit of the NuRD complex (nucleosome remodeling and deacetylase activities). Besides CHD proteins, NuRD contains several repressors like HDAC1/2, MTA2/3 and MBD2/3, arguing for a role as a transcriptional repressor. However, the subunit composition varies among cell- and tissue types and physiological conditions. In particular, it is unclear if CHD3 and CHD4 coexist in the same NuRD complex or whether they form distinct NuRD complexes with specific functions. We mapped the CHD composition of NuRD complexes in mammalian cells and discovered that they are isoform-specific, containing either the monomeric CHD3 or CHD4 ATPase. Both types of complexes exhibit similar intranuclear mobility, interact with HP1 and rapidly accumulate at UV-induced DNA repair sites. But, CHD3 and CHD4 exhibit distinct nuclear localization patterns in unperturbed cells, revealing a subset of specific target genes. Furthermore, CHD3 and CHD4 differ in their nucleosome remodeling and positioning behaviour in vitro. The proteins form distinct CHD3- and CHD4-NuRD complexes that do not only repress, but can just as well activate gene transcription of overlapping and specific target genes.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 114 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 114 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 24 21%
Student > Bachelor 17 15%
Student > Master 12 11%
Researcher 9 8%
Student > Doctoral Student 7 6%
Other 14 12%
Unknown 31 27%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 49 43%
Agricultural and Biological Sciences 17 15%
Medicine and Dentistry 7 6%
Neuroscience 3 3%
Chemistry 2 2%
Other 2 2%
Unknown 34 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 January 2018.
All research outputs
#13,332,723
of 22,999,744 outputs
Outputs from Nucleic Acids Research
#20,395
of 26,382 outputs
Outputs of similar age
#154,952
of 316,382 outputs
Outputs of similar age from Nucleic Acids Research
#162
of 300 outputs
Altmetric has tracked 22,999,744 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 26,382 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 316,382 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 300 others from the same source and published within six weeks on either side of this one. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.