| Title |
Cell-cycle arrest and acute kidney injury: the light and the dark sides
|
|---|---|
| Published in |
Nephrology Dialysis Transplantation, June 2015
|
| DOI | 10.1093/ndt/gfv130 |
| Pubmed ID | |
| Authors |
John A. Kellum, Lakhmir S. Chawla |
| Abstract |
Acute kidney injury (AKI) is a common consequence of systemic illness or injury and it complicates several forms of major surgery. Two major difficulties have hampered progress in AKI research and clinical management. AKI is difficult to detect early and its pathogenesis is still poorly understood. We recently reported results from multi-center studies where two urinary markers of cell-cycle arrest, tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) were validated for development of AKI well ahead of clinical manifestations-azotemia and oliguria. Cell-cycle arrest is known to be involved in the pathogenesis of AKI and this 'dark side' may also involve progression to chronic kidney disease. However, cell-cycle arrest has a 'light side' as well, since this mechanism can protect cells from the disastrous consequences of entering cell division with damaged DNA or insufficient bioenergetic resources during injury or stress. Whether we can use the light side to help prevent AKI remains to be seen, but there is already evidence that cell-cycle arrest biomarkers are indicators of both sides of this complex physiology. |
X Demographics
The data shown below were collected from the profiles of 38 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 11% |
| United Kingdom | 3 | 8% |
| Spain | 2 | 5% |
| France | 1 | 3% |
| Colombia | 1 | 3% |
| Argentina | 1 | 3% |
| Mexico | 1 | 3% |
| Venezuela, Bolivarian Republic of | 1 | 3% |
| India | 1 | 3% |
| Other | 4 | 11% |
| Unknown | 19 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 21 | 55% |
| Practitioners (doctors, other healthcare professionals) | 8 | 21% |
| Scientists | 5 | 13% |
| Science communicators (journalists, bloggers, editors) | 4 | 11% |
Mendeley readers
The data shown below were compiled from readership statistics for 134 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | <1% |
| Australia | 1 | <1% |
| Unknown | 132 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 20 | 15% |
| Other | 15 | 11% |
| Student > Ph. D. Student | 15 | 11% |
| Student > Bachelor | 13 | 10% |
| Student > Doctoral Student | 13 | 10% |
| Other | 29 | 22% |
| Unknown | 29 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 70 | 52% |
| Biochemistry, Genetics and Molecular Biology | 10 | 7% |
| Agricultural and Biological Sciences | 8 | 6% |
| Nursing and Health Professions | 3 | 2% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 1% |
| Other | 7 | 5% |
| Unknown | 34 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 620. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 December 2019.
All research outputs
#32,392
of 23,862,416 outputs
Outputs from Nephrology Dialysis Transplantation
#3
of 6,164 outputs
Outputs of similar age
#279
of 269,994 outputs
Outputs of similar age from Nephrology Dialysis Transplantation
#2
of 103 outputs
Altmetric has tracked 23,862,416 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,164 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one has done particularly well, scoring higher than 99% of its peers.
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We're also able to compare this research output to 103 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.