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A legion of potential regulatory sRNAs exists beyond the typical microRNAs microcosm

Overview of attention for article published in Nucleic Acids Research, September 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Mentioned by

blogs
1 blog
twitter
6 tweeters
googleplus
1 Google+ user

Citations

dimensions_citation
14 Dimensions

Readers on

mendeley
43 Mendeley
citeulike
1 CiteULike
Title
A legion of potential regulatory sRNAs exists beyond the typical microRNAs microcosm
Published in
Nucleic Acids Research, September 2015
DOI 10.1093/nar/gkv871
Pubmed ID
Authors

Ashwani Jha, Ganesh Panzade, Rajesh Pandey, Ravi Shankar

Abstract

Post ENCODE, regulatory sRNAs (rsRNAs) like miRNAs have established their status as one of the core regulatory elements of cell systems. However, large number of rsRNAs are compromised due to traditional approaches to identify miRNAs, limiting the otherwise vast world of rsRNAs mainly to hair-pin loop bred typical miRNAs. The present study has analyzed for the first time a huge volume of sequencing data from 4997 individuals and 25 cancer types to report 11 234 potentially regulatory small RNAs which appear to have deep reaching impact. The rsRNA-target interactions have been studied and validated extensively using experimental data from AGO-crosslinking, DGCR8 knockdown, CLASH, proteome and expression data. A subset of such interactions was also validated independently in the present study using multiple cell lines, by qPCR. Several of the potential rsRNAs have emerged as a critical cancer biomarker controlling some important spots of cell system. The entire study has been presented into an interactive info-analysis portal handling more than 260 GB of processed data. The possible degree of cell system regulation by sRNAs appears to be much higher than previously assumed.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
South Africa 1 2%
Czechia 1 2%
Belgium 1 2%
Denmark 1 2%
United States 1 2%
Unknown 38 88%

Demographic breakdown

Readers by professional status Count As %
Researcher 16 37%
Student > Ph. D. Student 10 23%
Student > Master 5 12%
Student > Bachelor 3 7%
Student > Doctoral Student 2 5%
Other 7 16%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 14 33%
Agricultural and Biological Sciences 14 33%
Computer Science 6 14%
Medicine and Dentistry 2 5%
Environmental Science 1 2%
Other 2 5%
Unknown 4 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 May 2016.
All research outputs
#2,597,675
of 22,828,180 outputs
Outputs from Nucleic Acids Research
#3,312
of 26,318 outputs
Outputs of similar age
#36,083
of 267,220 outputs
Outputs of similar age from Nucleic Acids Research
#45
of 301 outputs
Altmetric has tracked 22,828,180 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 26,318 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,220 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 301 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.