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A legion of potential regulatory sRNAs exists beyond the typical microRNAs microcosm

Overview of attention for article published in Nucleic Acids Research, September 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (88th percentile)
  • High Attention Score compared to outputs of the same age and source (89th percentile)

Mentioned by

blogs
1 blog
twitter
8 tweeters
googleplus
1 Google+ user

Readers on

mendeley
29 Mendeley
citeulike
1 CiteULike
Title
A legion of potential regulatory sRNAs exists beyond the typical microRNAs microcosm
Published in
Nucleic Acids Research, September 2015
DOI 10.1093/nar/gkv871
Pubmed ID
Authors

Ashwani Jha, Ganesh Panzade, Rajesh Pandey, Ravi Shankar, Jha, Ashwani, Panzade, Ganesh, Pandey, Rajesh, Shankar, Ravi

Abstract

Post ENCODE, regulatory sRNAs (rsRNAs) like miRNAs have established their status as one of the core regulatory elements of cell systems. However, large number of rsRNAs are compromised due to traditional approaches to identify miRNAs, limiting the otherwise vast world of rsRNAs mainly to hair-pin loop bred typical miRNAs. The present study has analyzed for the first time a huge volume of sequencing data from 4997 individuals and 25 cancer types to report 11 234 potentially regulatory small RNAs which appear to have deep reaching impact. The rsRNA-target interactions have been studied and validated extensively using experimental data from AGO-crosslinking, DGCR8 knockdown, CLASH, proteome and expression data. A subset of such interactions was also validated independently in the present study using multiple cell lines, by qPCR. Several of the potential rsRNAs have emerged as a critical cancer biomarker controlling some important spots of cell system. The entire study has been presented into an interactive info-analysis portal handling more than 260 GB of processed data. The possible degree of cell system regulation by sRNAs appears to be much higher than previously assumed.

Twitter Demographics

The data shown below were collected from the profiles of 8 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
South Africa 1 3%
Denmark 1 3%
United States 1 3%
Belgium 1 3%
Czech Republic 1 3%
Unknown 24 83%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 41%
Student > Ph. D. Student 6 21%
Student > Master 3 10%
Professor 2 7%
Student > Bachelor 2 7%
Other 4 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 48%
Biochemistry, Genetics and Molecular Biology 9 31%
Computer Science 3 10%
Environmental Science 1 3%
Physics and Astronomy 1 3%
Other 1 3%

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 May 2016.
All research outputs
#637,228
of 7,915,432 outputs
Outputs from Nucleic Acids Research
#746
of 10,526 outputs
Outputs of similar age
#26,817
of 229,703 outputs
Outputs of similar age from Nucleic Acids Research
#28
of 279 outputs
Altmetric has tracked 7,915,432 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 10,526 research outputs from this source. They receive a mean Attention Score of 4.4. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 229,703 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 279 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.