| Title |
Corticolimbic anatomical characteristics predetermine risk for chronic pain
|
|---|---|
| Published in |
Brain, May 2016
|
| DOI | 10.1093/brain/aww100 |
| Pubmed ID | |
| Authors |
Etienne Vachon-Presseau, Pascal Tétreault, Bogdan Petre, Lejian Huang, Sara E Berger, Souraya Torbey, Alexis T Baria, Ali R Mansour, Javeria A Hashmi, James W Griffith, Erika Comasco, Thomas J Schnitzer, Marwan N Baliki, A Vania Apkarian |
| Abstract |
Mechanisms of chronic pain remain poorly understood. We tracked brain properties in subacute back pain patients longitudinally for 3 years as they either recovered from or transitioned to chronic pain. Whole-brain comparisons indicated corticolimbic, but not pain-related circuitry, white matter connections predisposed patients to chronic pain. Intra-corticolimbic white matter connectivity analysis identified three segregated communities: dorsal medial prefrontal cortex-amygdala-accumbens, ventral medial prefrontal cortex-amygdala, and orbitofrontal cortex-amygdala-hippocampus. Higher incidence of white matter and functional connections within the dorsal medial prefrontal cortex-amygdala-accumbens circuit, as well as smaller amygdala volume, represented independent risk factors, together accounting for 60% of the variance for pain persistence. Opioid gene polymorphisms and negative mood contributed indirectly through corticolimbic anatomical factors, to risk for chronic pain. Our results imply that persistence of chronic pain is predetermined by corticolimbic neuroanatomical factors. |
X Demographics
The data shown below were collected from the profiles of 47 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 13% |
| United Kingdom | 5 | 11% |
| Spain | 3 | 6% |
| Canada | 3 | 6% |
| New Zealand | 2 | 4% |
| Korea, Republic of | 1 | 2% |
| Mexico | 1 | 2% |
| Sweden | 1 | 2% |
| Brazil | 1 | 2% |
| Other | 2 | 4% |
| Unknown | 22 | 47% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 31 | 66% |
| Scientists | 8 | 17% |
| Practitioners (doctors, other healthcare professionals) | 4 | 9% |
| Science communicators (journalists, bloggers, editors) | 4 | 9% |
Mendeley readers
The data shown below were compiled from readership statistics for 352 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Netherlands | 1 | <1% |
| Unknown | 350 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 54 | 15% |
| Researcher | 50 | 14% |
| Student > Master | 41 | 12% |
| Student > Bachelor | 37 | 11% |
| Other | 30 | 9% |
| Other | 76 | 22% |
| Unknown | 64 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 86 | 24% |
| Medicine and Dentistry | 69 | 20% |
| Psychology | 32 | 9% |
| Nursing and Health Professions | 24 | 7% |
| Agricultural and Biological Sciences | 18 | 5% |
| Other | 42 | 12% |
| Unknown | 81 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 550. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 March 2024.
All research outputs
#44,731
of 26,017,215 outputs
Outputs from Brain
#47
of 7,800 outputs
Outputs of similar age
#854
of 316,170 outputs
Outputs of similar age from Brain
#2
of 79 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,800 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.9. This one has done particularly well, scoring higher than 99% of its peers.
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We're also able to compare this research output to 79 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.